Low concentrations of Lactobacillus rhamnosus GG ( Yoba®) are safe in male Drosophila melanogaster

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dc.contributor.authorKeneth Iceland, Kasozi
dc.contributor.authorAisha, Bukenya
dc.contributor.authorEjike, Daniel Eze
dc.contributor.authorJosephine, Kasolo
dc.contributor.authorDickson Stuart, Tayebwa
dc.contributor.authorFred, Ssempijja
dc.contributor.authorJoy, Suubo
dc.contributor.authorAndrew, Tamale
dc.contributor.authorIsaac, Echoru
dc.contributor.authorIbrahim, Ntulume
dc.contributor.authorSarah, Kemuma Onkoba
dc.contributor.authorLisa Nkatha, Micheni
dc.contributor.authorEmmanuel Tiyo, Ayikobua
dc.contributor.authorOscar Hilary, Asiimwe
dc.contributor.authorMuhamudu, Kalange
dc.date.accessioned2019-06-14T09:37:09Z
dc.date.available2019-06-14T09:37:09Z
dc.date.issued2019
dc.description.abstractObjective: The purpose of the study was to generate information on the safety of probiotics, thus the study objectives were to evaluate the effects of Yoba ® on basic physiochemical properties. The study assessed male w1118 Drosophila melanogaster which were provided food supplemented with Yoba ® at 1%, 3%, 6%, and 12% on motor function, total protein, catalase activity, and hydrogen peroxide scavenging activity and lifespan. Results: Yoba® at high concentration (≥ 6%) increased locomotor activity in Drosophila melanogaster, however, total protein, catalase, and hydrogen peroxide scavenging activity were significantly higher at 1% Yoba ® compared to 3%, 6%, and 12% Yoba ®. Yoba consumed at 1% was associated with greater physiological benefits in Drosophila melanogaster. Findings in the study offer a rationale for the consumption of Yoba ® at 1% in humans as is currently being promoted by the Yoba for Life consortium, however, high concentrations of Yoba ® would disrupt physiological function as shown by this study.en_US
dc.description.sponsorshipKabale Universityen_US
dc.identifier.citationKasozi et alen_US
dc.identifier.urihttp://hdl.handle.net/20.500.12493/170
dc.publisherBMC Res Notesen_US
dc.relation.ispartofseries;(2019) 12:269
dc.subjectProbiotics, Yoba for life, Nutritional toxicology, Yoghurt, Food supplements, Catalase, Hydrogen peroxide scavenging, Agingen_US
dc.titleLow concentrations of Lactobacillus rhamnosus GG ( Yoba®) are safe in male Drosophila melanogasteren_US
dc.typeArticleen_US

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