Low concentrations of Lactobacillus rhamnosus GG ( Yoba®) are safe in male Drosophila melanogaster
Date
2019
Authors
Keneth Iceland, Kasozi
Aisha, Bukenya
Ejike, Daniel Eze
Josephine, Kasolo
Dickson Stuart, Tayebwa
Fred, Ssempijja
Joy, Suubo
Andrew, Tamale
Isaac, Echoru
Ibrahim, Ntulume
Journal Title
Journal ISSN
Volume Title
Publisher
BMC Res Notes
Abstract
Objective: The purpose of the study was to generate information on the safety of probiotics, thus the study objectives
were to evaluate the effects of Yoba ® on basic physiochemical properties. The study assessed male w1118
Drosophila melanogaster which were provided food supplemented with Yoba ® at 1%, 3%, 6%, and 12% on motor function, total protein, catalase activity, and hydrogen peroxide scavenging activity and lifespan.
Results: Yoba® at high concentration (≥ 6%) increased locomotor activity in Drosophila melanogaster, however, total
protein, catalase, and hydrogen peroxide scavenging activity were significantly higher at 1% Yoba
® compared to 3%, 6%, and 12% Yoba ®. Yoba consumed at 1% was associated with greater physiological benefits in Drosophila melanogaster.
Findings in the study offer a rationale for the consumption of Yoba ® at 1% in humans as is currently being promoted by the Yoba for Life consortium, however, high concentrations of Yoba ® would disrupt physiological function as shown by this study.
Description
Keywords
Probiotics, Yoba for life, Nutritional toxicology, Yoghurt, Food supplements, Catalase, Hydrogen peroxide scavenging, Aging
Citation
Kasozi et al