Etracarpidium Conophorum Extract Exhibits Anti-Fatigue Activity in Rats Via Reduced Protein Catabolism, Increased Antioxidant Status and Delayed Lactate Elevation
Ugochukwu Vincent, Igbokwe
Ejike, Daniel Eze
Moses Dele, Adams
Karimah Mohammed, Rabiu,
Prisca Ojochogu, Ajeka
Adam Moyosore, Afodun
FUDMA Journal of Sciences (FJS)
Thirty rats of both sexes were assigned into 5 categories of six animals apiece. Animals in the unadministered (control) group were placed on distilled water. Group 1M and Group 1F animals were administered 500 mg/kg body weight (b.w) of T. conophorum aqueous nut extract whereas animals in Group 2M and Group 2F were administered 750 mg/kg dosage of the extricate (0.5 ml) orally once daily for 32 days. Phytoconstituents present in the extract include: saponins, flavonoids, tannins, phenols and alkaloids. The extract at 750mg/kg b.w notably (p<0.05) raised extracellular glucose in masculine rats when matched with males that received 500 mg/kg b.w. The 500 mg/kg dose of the extract appreciably (p<0.05) elevated BUN in both sexes, but with reduction in both groups at 750 mg/kg b.w when juxtaposed with their respective untreated animals. The extract at 500 mg/kg b.w increased LDH activity in male group when compared with male rats that received 750 mg/kg dose. The 750-extract dosage did not statistically (p>0.05) alter LDH activity in both sexes. The extract at 500 and 750mg/kg b.w increased the 3rd‒6th swim in male rats. Substantive (p<0.05) rise in swimming endurance time was first noticed at the 2nd swim when matched up with the control and group treated 500 mg/kg b.w, in female rats. Sequel to these research findings, it is hypothesized that the anti-weakness effect of T. conophorum might be adduced to delayed increase in lactate and reduction in protein catabolism.
Fatigue , Tetracarpidium conophorum , Euphorbiaceae , Swim endurance time , Lactate.