Etracarpidium Conophorum Extract Exhibits Anti-Fatigue Activity in Rats Via Reduced Protein Catabolism, Increased Antioxidant Status and Delayed Lactate Elevation

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dc.contributor.authorUgochukwu Vincent, Igbokwe
dc.contributor.authorEjike, Daniel Eze
dc.contributor.authorMoses Dele, Adams
dc.contributor.authorKarimah Mohammed, Rabiu,
dc.contributor.authorIliya, Ezekiel
dc.contributor.authorPrisca Ojochogu, Ajeka
dc.contributor.authorAdam Moyosore, Afodun
dc.date.accessioned2023-02-22T09:45:35Z
dc.date.available2023-02-22T09:45:35Z
dc.date.issued2021
dc.description.abstractThirty rats of both sexes were assigned into 5 categories of six animals apiece. Animals in the unadministered (control) group were placed on distilled water. Group 1M and Group 1F animals were administered 500 mg/kg body weight (b.w) of T. conophorum aqueous nut extract whereas animals in Group 2M and Group 2F were administered 750 mg/kg dosage of the extricate (0.5 ml) orally once daily for 32 days. Phytoconstituents present in the extract include: saponins, flavonoids, tannins, phenols and alkaloids. The extract at 750mg/kg b.w notably (p<0.05) raised extracellular glucose in masculine rats when matched with males that received 500 mg/kg b.w. The 500 mg/kg dose of the extract appreciably (p<0.05) elevated BUN in both sexes, but with reduction in both groups at 750 mg/kg b.w when juxtaposed with their respective untreated animals. The extract at 500 mg/kg b.w increased LDH activity in male group when compared with male rats that received 750 mg/kg dose. The 750-extract dosage did not statistically (p>0.05) alter LDH activity in both sexes. The extract at 500 and 750mg/kg b.w increased the 3rd‒6th swim in male rats. Substantive (p<0.05) rise in swimming endurance time was first noticed at the 2nd swim when matched up with the control and group treated 500 mg/kg b.w, in female rats. Sequel to these research findings, it is hypothesized that the anti-weakness effect of T. conophorum might be adduced to delayed increase in lactate and reduction in protein catabolism.en_US
dc.description.sponsorshipKabale Universityen_US
dc.identifier.urihttp://hdl.handle.net/20.500.12493/1030
dc.language.isoenen_US
dc.publisherFUDMA Journal of Sciences (FJS)en_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectFatigueen_US
dc.subjectTetracarpidium conophorumen_US
dc.subjectEuphorbiaceaeen_US
dc.subjectSwim endurance timeen_US
dc.subjectLactate.en_US
dc.titleEtracarpidium Conophorum Extract Exhibits Anti-Fatigue Activity in Rats Via Reduced Protein Catabolism, Increased Antioxidant Status and Delayed Lactate Elevationen_US
dc.typeArticleen_US

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