Borassus aethiopum (Mart.) ethanol fruit extract reverses alloxan-treatment alterations in experimental animals

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dc.contributor.authorMoses Dele, Adams
dc.contributor.authorEjike, Daniel Eze
dc.date.accessioned2023-02-22T09:44:49Z
dc.date.available2023-02-22T09:44:49Z
dc.date.issued2022
dc.description.abstractBACKGROUND: Borassus aethiopum fruit is claimed to be used for the management of diabetes without scientific validation. OBJECTIVE: This study seeks to evaluate the antihyperglycaemic activity of ethanol fruit extract of Borassus aethiopum in alloxan-induced diabetic rats. METHODS: 36 rats were placed in six groups (i-vi) (n = 6). Animals in group i (standard) were given 0.4 mls of distilled water (d.w) whereas the ones assigned to group ii, iii, iv, v and vi which were induced into diabetes (by intake of 140 mg/kg body weight [b.w] of alloxan) were also respectively given d.w, 50 mg/kg b.w of metformin, 25, 50 and 100 mg/kg b.w of ethanol fruit extract of Borassus aethiopum, once daily for 14 days. RESULTS: Flavonoid found in the extract (24.04 mg/ml) occurred the most with phenolic (0.35 mg/ml) being the least. While alloxan substantially (p < 0.05) increased the levels of some biological molecules and enzyme activity, it lowered those of others. The extract however significantly (p < 0.05) reversed all the alloxan-induced alterations, with the extract at 100 mg/kg b.w producing figures that compared (p > 0.05) well with those of the d.w treated non-diabetic animals and metformin-treated diabetic animals. The extract also renewed the wholeness of histological damage in the pancreas. CONCLUSION: The bioactive agents of B. aethiopum presented antihyperglycaemic property by preventing diabetes via reversal of alloxan-treatment alterations in the animalsen_US
dc.description.sponsorshipKabale Universityen_US
dc.identifier.urihttp://hdl.handle.net/20.500.12493/1029
dc.language.isoenen_US
dc.publisherMediterranean Journal of Nutrition and Metabolism 15 (2022) 429–44en_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectDiabetes mellitusen_US
dc.subjectBorassus aethiopumen_US
dc.subjectinsulinen_US
dc.subjectArecaceaeen_US
dc.titleBorassus aethiopum (Mart.) ethanol fruit extract reverses alloxan-treatment alterations in experimental animalsen_US
dc.typeArticleen_US

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