Ugochukwu, Oliver Ukachi
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Date
2023-02-09
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press
Abstract
OBJECTIVES: This study looked at how CMSO affected male Wistar albino rats' liver damage
caused by bisphenol A.
METHODS: The standard HPLC method was used to assess the CMSO's phenolic content. Then, six
(n = 8) groups of forty-eight (48) male Wistar rats (150 20 g) each received either CMSO or olive oil
before being exposed to BPA for 42 days. Groups: A (one milliliter of olive oil, regardless of weight),
B (BPA 100 mg/kg body weight (BW)), C (CMSO 7.5 mg/kg BW), D (CMSO 7.5 mg/kg BW + BPA
100 mg/kg BW), E (CMSO 5.0 mg/kg BW + BPA 100 mg/kg BW), and F (CMSO 2.5 mg/kg BW +
BPA 100 mg/kg BW).
KEY FINDINGS: A surprising abundance of flavonoids, totaling 17.8006 10.95 g/100 g, were found
in the HPLC data. Malondialdehyde, liver enzymes, reactive oxygen species, total bilirubin, and direct
bilirubin levels were all significantly elevated by BPA (p 0.05). Additionally, nuclear factor-B,
interleukin-6, interleukin-1, tumor necrosis factor, and histological alterations were all considerably (p
0.05) caused by BPA. The altered biochemical markers and histology were, however, noticeably
recovered by CMSO to a level that was comparable to the control.
CONCLUSION: Due to the abundance of flavonoid components in the oil, CMSO protects the liver
from BPA-induced hepatotoxicity by lowering oxidative stress and inflammatory reactions
Description
Keywords
Bisphenol A, Hepatotoxicity, Oxidative stress, Anti-inflammation, Antioxidant, Cucumeropsis mannii, Flavonoids profile