Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats

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dc.contributor.authorUgochukwu Vincent, Igbokwe
dc.contributor.authorEjike, Daniel Eze
dc.contributor.authorMoses Dele, Adams
dc.contributor.authorKarimah Mohammed, Rabiu
dc.contributor.authorIliya, Ezekiel
dc.contributor.authorPrisca Ojochogu, Ajeka
dc.contributor.authorPeace Ogechukwu, Okpara
dc.date.accessioned2023-02-22T09:08:39Z
dc.date.available2023-02-22T09:08:39Z
dc.date.issued2021
dc.description.abstractThis work focusses on comparative determination of the effects of plant extracts: bitter leaf (BL), sour lime (SL), grape (G), pawpaw (PP) and unripe pineapple (UPA) in female rats induced into malaria with Plasmodiumberghei. Thirty female rats weighing 120-160 g were allotted into five groups (n=6). Group A (negative control) were infected but not treated. Animals in Groups B–E which were infected were given 500 mg/kg body weight (BW) of malanter DS (reference antimalarial drug), 500 mg/kg BW of BL, 250 mg/kg BW each of SL and BL as well as 250 mg/kg BW each of G, PP and UPA. Treatment was done orally once daily for 14 days after which a few related analyses were carried out. Before treatment, parasitemia count of animals in groups B-E was substantially (p<0.05) higher when juxtaposed with group A. AST and ALT activities was substantively (p<0.05) elevated in group B-E when matched with group A. Plasmodium berghei induction notably (p<0.05) lowered white blood cell (WBC) and monocyte (Mono) levels at all groups. After 7 days of treatment, the extracts and drug which appreciably (p<0.05) lowered plasmodium count, RBC, WBC, PCV, Hb, Plat, Lymph, Mono, Granul levels did not meaningfully(p>0.05) affect the activities of ALP, AST and ALT. After 14 days of treatment, the extracts and drug exceptionally (p<0.05) reduced plasmodium count, WBC and ALP activity at all groups. These results give suggestive evidence that the plant extracts either singly or combined, could be a promising anti-plasmodial candidate.en_US
dc.description.sponsorshipKabale Universityen_US
dc.identifier.issnSSN online: 2616-1370
dc.identifier.urihttp://hdl.handle.net/20.500.12493/1022
dc.language.isoenen_US
dc.publisherFUDMA Journal of Sciences (FJS)en_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectMalariaen_US
dc.subjectPlasmodium bergheien_US
dc.subjectVernonia amygdalinaen_US
dc.subjectParasitemia.en_US
dc.titleAnti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Ratsen_US
dc.typeArticleen_US

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