Diversity of Mycobacterium tuberculosis Complex Lineages Associated with Pulmonary Tuberculosis in Southwestern, Uganda

Simple item page
dc.contributor.authorLisa, Nkatha Micheni
dc.contributor.authorKennedy, Kassaza
dc.contributor.authorHellen, W. Kinyi
dc.date.accessioned2021-07-30T16:58:55Z
dc.date.available2021-07-30T16:58:55Z
dc.date.issued2021
dc.description.abstractUganda is among the 22 countries in the world with a high burden of tuberculosis. The southwestern region of the country has consistently registered a high TB/HIV incidence rate. This study is aimed at characterizing the Mycobacterium tuberculosis complex (MTBC) genotypic diversity in southwestern Uganda. A total of 283 sputum samples from patients with pulmonary tuberculosis were genotyped using specific single nucleotide polymorphism markers for lineages 3 and 4. Most of the patients were males with a mean age of 34. The lineage 4 Ugandan family was found to be the most dominant strains accounting for 59.7% of all cases followed by lineage 3 at 15.2%. The lineage 4 non-Ugandan family accounted for 14.5% of all cases while 4.2% showed amplification for both lineage 4 and lineage 3. Eighteen samples (6.4%) of the strains remained unclassified since they could not be matched to any lineage based on the genotyping technique used. This study demonstrates that a wide diversity of strains is causing pulmonary tuberculosis in this region with those belonging to the lineage 4 Ugandan family being more predominant. However, to confirm this, further studies using more discriminative genotyping methods are necessary.en_US
dc.description.sponsorshipKabale Universityen_US
dc.identifier.urihttps://doi.org/10.1155/2021/5588339
dc.identifier.urihttp://hdl.handle.net/20.500.12493/512
dc.publisherHindawien_US
dc.relation.ispartofseries;5588339
dc.subjectMycobacterium tuberculosis, Pulmonary Tuberculosisen_US
dc.titleDiversity of Mycobacterium tuberculosis Complex Lineages Associated with Pulmonary Tuberculosis in Southwestern, Ugandaen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Diversity of Microbacterium tuberculosis complex lineages.pdf
Size:
583.31 KB
Format:
Adobe Portable Document Format
Description:
Main Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

School of Medicine (KABSOM)