ucumeropsis mannii seed oil protects against Bisphenol A- induced testicular mitochondrial damages

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dc.contributor.authorPatrick Maduabuchi, Aja
dc.contributor.authorHilary Akobi, Ogwoni
dc.contributor.authorPeter Chinedu, Agu
dc.contributor.authorEjike Ugbala, Ekpono
dc.contributor.authorJoshua Nonso, Awoke
dc.contributor.authorOliver Ugochukwu, Ukachi
dc.contributor.authorObasi Uche, Orji
dc.contributor.authorBoniface Anthony, Ale
dc.contributor.authorChinonso Peter, Nweke
dc.contributor.authorEsther Ugo, Alum
dc.contributor.authorDarlington C., Chukwu
dc.contributor.authorChristian E., Offor
dc.contributor.authorAtamgba Agbor, Asuk
dc.contributor.authorEjike, Daniel Eze
dc.contributor.authorOjochenemi E., Yakubu
dc.contributor.authorJ. B., Akob
dc.contributor.authorOnyedika Gabriel, Ani
dc.contributor.authorChinaza Godswill, Awuchi
dc.date.accessioned2023-02-22T09:12:55Z
dc.date.available2023-02-22T09:12:55Z
dc.date.issued2022
dc.description.abstracthere has been increasing search for the ameliorative properties of seed oils against toxicants. bisphenol A acts as an estrogenic endocrine-disrupting chemical capable of causing male infertility. This study aimed to explore Cucumeropsis mannii seed oil effects against mitochondrial damage in rats using bisphenol A. Forty-eight rats were randomly assigned to six groups (n = 6) of eight rats each and fed the same food and water for 6 weeks. The group A rats were given 1 mL olive oil, while the ones in group B were given bisphenol A at 100 mL/kg body weight via oral route. Group C received C. mannii seed oil 7.5 mL/kg body weight C. mannii seed oil, while group D, group E, and group F were pre-administered bisphenol A at 100 mL/kg body weight, followed by treatment with C. mannii seed oil at 7.5, 5, and 2.5 mL/kg body weight, respectively. Antioxidant enzymes, glutathione, reactive oxygen species, testicular volume, malon- dialdehyde, body weight, and testicular studies were done using standard methods. The results of the bisphenol A-administered group showed a significant decrease in the antioxidant enzymes, glutathione, body weight, and testicular volume with eleva- tion in the levels of reactive oxygen species, malondialdehyde, and testicular indices. BPA + CMSO-treated group showed a significant increase in GPx activity compared with BPA-exposed rats. CMSO treatment significantly increased catalase activity in comparison with that of rats exposed to BPA. Remarkably, C. mannii seed oil and bi- sphenol A co-administration significantly reversed the abnormalities observed in the dysregulated biochemical biomarkers. Our findings suggest that C. mannii seed oil has considerable antioxidant potential which can be explored in therapeutic development against systemic toxicity induced by exposure to bisphenol A. Cucumeropsis mannii seed oil protects against bisphenol A-induced testicular mitochondria damages.en_US
dc.description.sponsorshipKabale Universityen_US
dc.identifier.urihttp://hdl.handle.net/20.500.12493/1028
dc.language.isoenen_US
dc.publisherFood Science & Nutritutionen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectantioxidantsen_US
dc.subjectBisphenol Aen_US
dc.subjectCucumeropsis manniien_US
dc.subjectmitochondriaen_US
dc.subjectsystemic toxicityen_US
dc.titleucumeropsis mannii seed oil protects against Bisphenol A- induced testicular mitochondrial damagesen_US
dc.typeArticleen_US

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