Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 IgG in Juba, South Sudan, 20201

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dc.contributor.authorAndrew, Baguma
dc.contributor.authorJuma John, Hassen
dc.contributor.authorSheila, K. Baya
dc.contributor.authorJoseph, F. Wamala
dc.date.accessioned2021-07-30T18:19:16Z
dc.date.available2021-07-30T18:19:16Z
dc.date.issued2021
dc.description.abstractRelatively few coronavirus disease cases and deaths have been reported from sub-Saharan Africa, although the extent of its spread remains unclear. During August 10–September 11, 2020, we recruited 2,214 participants for a representative household-based cross-sectional serosurvey in Juba, South Sudan. We found 22.3% of participants had severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) receptor binding domain IgG titers above prepandemic levels. After accounting for waning antibody levels, age, and sex, we estimated that 38.3% (95% credible interval 31.8%–46.5%) of the population had been infected with SARS-CoV-2. At this rate, for each PCR–confi rmed SARS-CoV-2 infection reported by the Ministry of Health, 103 (95% credible interval 86–126) infections would have been unreported, meaning SARS-CoV-2 has likely spread extensively within Juba. We also found diff erences in background reactivity in Juba compared with Boston, Massachusetts, USA, where the immunoassay was validated. Our fi ndings underscore the need to validate serologic tests in sub-Saharan Africa populations.en_US
dc.description.sponsorshipKabale Universityen_US
dc.identifier.uriDOI: https://doi.org/10.3201/eid2706.210568
dc.identifier.urihttp://hdl.handle.net/20.500.12493/516
dc.publisherJapan Cooperative Medical Sciences Program—Virtual Workshopen_US
dc.subjectSeroprevalence of Severe Acute Respiratory Syndrome Coronavirusen_US
dc.titleSeroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 IgG in Juba, South Sudan, 20201en_US
dc.typeArticleen_US

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