Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster

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dc.contributor.authorHerbert Izo, Ninsiima
dc.contributor.authorEmmanuel Tiyo, Ayikobua
dc.contributor.authorJosephine, Kasolo
dc.contributor.authorKeneth Iceland, Kasozi
dc.contributor.authorEjike, Daniel Eze
dc.date.accessioned2020-07-09T08:10:52Z
dc.date.available2020-07-09T08:10:52Z
dc.date.issued2020
dc.description.abstractBackground: The Phosphatase and tensin-induced putative kinase 1 (PINK1B9) mutant for Drosophila melanogaster is a key tool that has been used in assessing the pathology of Parkinsonism and its possible remedy. This research was targeted toward determining the effects of ethanolic extract of propolis, with levodopa therapy in the management of Parkinsonism. Method: The PINK1B9 flies were divided into groups and fed with the different treatment doses of ethanoic extract of propolis. The treatment groups were subjected to 21 days of administration of propolis and the levodopa at different doses after which percentage climbing index, antioxidant activity and lifespan studies were done. Results: Propolis alone improved motor activity, antioxidant and lifespan in Drosophila melanogaster than in PINK1 flies. Propolis in combination with levodopa significantly (P<0.05) improved physiological parameters at higher than lower concentrations in Parkinsonism Drosophila melanogaster demonstrating its importance in managing side effects associated with levodopa. Conclusion: Propolis is a novel candidate as an alternative and integrative medicinal option to use in the management of Parkinsonism in both animals and humans at higher concentrations.en_US
dc.description.sponsorshipKabale Universityen_US
dc.identifier.urihttp://hdl.handle.net/20.500.12493/439
dc.language.isoen_USen_US
dc.publisherJournal of Complementary and Integrative Medicineen_US
dc.subjectaging, antioxidant activity, catalase, climbing index, Drosophila melanogaster, Levodopa induced dyskinesia, lifespan, oxidative stress, Parkinson’s disease, Parkinsonism, PINK1B9, propolisen_US
dc.titleSynergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogasteren_US
dc.typeArticleen_US

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