Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance

Simple item page
dc.contributor.authorKeneth Iceland, Kasozi
dc.contributor.authorEwan Thomas, MacLeod
dc.contributor.authorCharles, Waiswa
dc.contributor.authorMichael, Mahero
dc.contributor.authorIbrahim, Ntulume
dc.contributor.authorSusan Christina, Welburn
dc.date.accessioned2023-02-02T05:39:26Z
dc.date.available2023-02-02T05:39:26Z
dc.date.issued2022-08-23
dc.description.abstractBackground: African trypanocide resistance is an emerging public health emergency whose control requires a revisit on farmer’s knowledge, attitudes, and practices in developing countries. African animal trypanocide resistance (AATr) is rife in an environment where drug use and policy decisions are disjointed. The objective of the study was to identify community factors responsible for the development of AATr. This was important since diminazene aceturate (DA), isometamidium chloride (ISM), and homidium bromide (HB) have existed for over 30 years and no new drugs have been provided to farmers. Methods: An electronic keyword search across 12 databases was conducted using a search criterion from 1806 to June 2022. This generated a total of 24 publications, but after removing duplicates, review articles, and nonrelated articles, a total of eight papers were included in the analysis by following the PRISMA checklist. A meta-analysis was conducted on the data extracted and the risk ratio and inverse variance at 95% confidence interval were calculated using RevMan®. Results: All the eight articles in the study showed that DA was the most preferred trypanocide in both West and Eastern Africa. Poor farmer knowledge of AATr and limited drug options were major drivers for trypanocide resistance. In addition, farmer treatments, use of untrained personnel, poor administration, poor dosing, and preparation of trypanocides were major drivers for the development of AATr and similarities were identified in DA and ISM practices (P = 0.13). Conclusions: AATr is spread in developing countries due to a lack of community knowledge, attitudes, and drug-use practices. This situation could be reversed through interdisciplinary collaborations in endemic communities by promoting effective treatments and responsible drug handling.en_US
dc.description.sponsorshipKabale Universityen_US
dc.identifier.citationKasozi, K.I.; MacLeod, E.T.; Waiswa, C.; Mahero, M.; Ntulume, I.; Welburn, S.C. Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance. Trop. Med. Infect. Dis. 2022, 7, 205. https://doi.org/10.3390/ tropicalmed7090205en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12493/928
dc.language.isoenen_US
dc.publisherTropical Medicine and Infectious Diseaseen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectTrypanocide resistanceen_US
dc.subjectTrypanosomiasisen_US
dc.subjectHuman African trypanosomiasisen_US
dc.subjectAnimal African trypanosomiasisen_US
dc.subjectGlobal healthen_US
dc.subjectOne healthen_US
dc.subjectCommunity practices attitudes and practicesen_US
dc.subjectAATren_US
dc.titleSystematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistanceen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
tropicalmed-07-00205.pdf
Size:
667.86 KB
Format:
Adobe Portable Document Format
Description:
Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

School of Medicine (KABSOM)