Kabale University Digital Repository (KAB-DR)
    • Login
    View Item 
    •   KAB-DR Home
    • Research Articles
    • School of Medicine (KABSOM)
    • View Item
    •   KAB-DR Home
    • Research Articles
    • School of Medicine (KABSOM)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents

    Thumbnail
    View/Open
    Main Article (433.9Kb)
    Date
    2018-06-29
    Author
    Joseph Obiezu, Chukwujekwu Ezeonwumelu
    Muhammad, Ntale
    Steve, Okwudili Ogbonnia
    Ezera, Agwu
    Julius, Kihdze Tanayen
    Ahmed, Adebowale Adedeji
    Okonkwo, Chukwudi Onyeka
    Ambrose, Amamchukwu Akunne
    Jennifer, Chibuogwu Ebosie
    Frederick, Byarugaba
    Metadata
    Show full item record
    Abstract
    Oral lesions, diarrhoea, Pneumocystis carinii pneumonia, tuberculosis and urinary tract infections are some of the opportunistic infections (OIs) which arise when the CD4 cells of the HIV/AIDS patient fall below 200 cells/mm3. HIV/AIDS infection complications include tissue damage from oral lesions accompanied with pains. Pain is a disagreeable sensory and sensitive experience associated with actual or potential tissue damage. This condition requires immediate treatment with analgesics and antibiotics. However, the inability of rural dwellers to afford readily available drugs is a consequence for using herbs like Bidens pilosa whose local usefulness in the management of oral lesions of HIV/AIDS has not been proven scientifically. Therefore, the objective of this study was to provide the scientific basis in rats for the traditional healers’ use of Bidens pilosa leaves’ extracts in managing pain associated with oral lesions of HIV/AIDS patients in South Western Uganda. Assessment of the analgesic effects of Bidens pilosa was conducted using acetic acid in mice, formalin-induced pain and tail flick methods in rats. Both aqueous and ethanolic extracts of the leaves of Bidens pilosa produced statistically significant dose dependent inhibition of acetic acid induced pain, non dose dependent pain reduction in formalin induced pain, (p < 0.05; student t-test) and non dose dependent tail withdrawal pattern (p < 0.05, Multivariate ANOVA test). Hence, we conclude that extracts of Bidens pilosa have an analgesic basis for their local use in treatment of oral lesions associated pain in HIV/AIDS patients in South-Western Uganda.
    URI
    http://hdl.handle.net/20.500.12493/169
    Collections
    • School of Medicine (KABSOM) [110]

    KAB-DR
    Contact Us | Send Feedback
    Kabale University
     

     

    Browse

    All of KAB-DRCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    KAB-DR
    Contact Us | Send Feedback
    Kabale University