Browsing by Author "Heydenreich, Matthias"

Now showing 1 - 2 of 2
  • Thumbnail Image
    ItemOpen Access
    A coumestan and a coumaronochromone from Millettia lasiantha
    (Elservier, 2023) Buyinza, Daniel; Derese, Solomon; Ndakala , Albert; Heydenreich, Matthias; Yenesew , Abiy; Oriko, Richard
    The manuscript describes the phytochemical investigation of the roots, leaves and stem bark of Millettia lasiantha resulting in the isolation of twelve compounds including two new isomeric isoflavones lascoumestan and lascoumaronochromone. The structures of the new compounds were determined using different spectroscopic techniques.
  • Thumbnail Image
    ItemOpen Access
    Cytotoxicity of isoflavones from Millettia dura
    (Taylor & Francis, 2019) Buyinza, Daniel; Yang, Li Jun; Derese, Solomon; Ndakala, Albert; Coghi, Paolo; Heydenreich, Matthias; Wong, Vincent Kam Wai; Möller, Heiko M.; Yenesew, Abiy
    The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 lM. Durmillone was the most active with IC50 values of 6.6 lM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 ¼ 58.4 lM), LO2 hepatocytes (IC50 78.7 lM) and CCD19Lu fibroblasts (IC50 >100 lM).