Cytotoxicity of isoflavones from Millettia dura

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buyinza et al., 2019.pdf (696.24 KB)

Date

2019

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Publisher

Taylor & Francis

Abstract

The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 lM. Durmillone was the most active with IC50 values of 6.6 lM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 ¼ 58.4 lM), LO2 hepatocytes (IC50 78.7 lM) and CCD19Lu fibroblasts (IC50 >100 lM).

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Keywords

Millettia dura, Leguminosae, isoflavone, cytotoxicity

Citation

Daniel Buyinza, Li Jun Yang, Solomon Derese, Albert Ndakala, Paolo Coghi, Matthias Heydenreich, Vincent Kam Wai Wong, Heiko M. Möller & Abiy Yenesew (2019): Cytotoxicity of isoflavones from Millettia dura, Natural Product Research, DOI: 10.1080/14786419.2019.1660335

URI

http://hdl.handle.net/20.500.12493/2940

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Faculty of Science (FSC)