Cytotoxicity of isoflavones from Millettia dura
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Date
2019
Authors
Buyinza, Daniel
Yang, Li Jun
Derese, Solomon
Ndakala, Albert
Coghi, Paolo
Heydenreich, Matthias
Wong, Vincent Kam Wai
Möller, Heiko M.
Yenesew, Abiy
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis
Abstract
The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 lM. Durmillone was the most active with IC50 values of 6.6 lM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 ¼ 58.4 lM), LO2 hepatocytes (IC50 78.7 lM) and CCD19Lu fibroblasts (IC50 >100 lM).
Description
Keywords
Millettia dura, Leguminosae, isoflavone, cytotoxicity
Citation
Daniel Buyinza, Li Jun Yang, Solomon Derese, Albert Ndakala, Paolo Coghi, Matthias Heydenreich, Vincent Kam Wai Wong, Heiko M. Möller & Abiy Yenesew (2019): Cytotoxicity of isoflavones from Millettia dura, Natural Product Research, DOI: 10.1080/14786419.2019.1660335