A Revised Protecting Group Strategy Enables a Divergent Synthesis of Prenylated Isoflavones from Psoralea corylifolia

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dc.contributor.authorGliszczinskia Sarah von Chamier
dc.contributor.authorSperlicha Eric
dc.contributor.authorKellinga Alexandra
dc.contributor.authorKwesiga George
dc.contributor.authorSchmidt Bernd
dc.date.accessioned2025-06-13T09:36:35Z
dc.date.available2025-06-13T09:36:35Z
dc.date.issued2025
dc.description.abstractThree bioactive prenylated isoflavone natural products were synthesized for the first time, using a combination of Pd-catalyzed Suzuki–Miyaura coupling for installing the B-ring, microwave-promoted Claisen rearrangement of allyl ethers, and Ru-catalyzed olefin cross me tathesis for obtaining the prenyl substituents. Careful consideration of the protecting group strategy turned out to be vital for the success of these total syntheses.
dc.identifier.citationvon Chamier Gliszczinski, S., Sperlich, E., Kelling, A., Kwesiga, G., & Schmidt, B. (2025). A Revised Protecting Group Strategy Enables a Divergent Synthesis of Prenylated Isoflavones from Psoralea corylifolia. Synthesis, 57(11), 1833-1847.
dc.identifier.other10.1055/a-2501-4796;
dc.identifier.urihttp://hdl.handle.net/20.500.12493/2918
dc.language.isoen
dc.publisherSynthesis
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United Statesen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/
dc.subjectisoflavones
dc.subjectSuzuki coupling
dc.subjectClaisen rearrangement
dc.subjectole fin metathesis
dc.subjectprotecting groups
dc.titleA Revised Protecting Group Strategy Enables a Divergent Synthesis of Prenylated Isoflavones from Psoralea corylifolia
dc.typeArticle

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