Browsing by Author "Zirintunda, Gerald"

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    Cerebral Cortical Activity During Academic Stress Amongst Undergraduate Medical Students at Kampala International University (Uganda)
    (Kabale University, 2022) Mujinya, Regan; Kalange, Muhamudu; Ochieng, Juma John; Ninsiima, Herbert Izo; Eze, Ejike Daniel; Afodun, Adam Moyosore; Nabirumbi, Ritah; Sulaiman, Sheu Oluwadare; Kairania, Emmanuel; Echoru, Isaac; Okpanachi, Alfred Omachonu; Matama, Kevin; Asiimwe, Oscar Hilary; Nambuya, Grace; Usman, Ibe Michael; Obado, Osuwat Lawrence; Zirintunda, Gerald; Ssempijja, Fred; Nansunga, Miriam; Matovu, Henry; Ayikobua, Emmanuel Tiyo; Nganda, Ponsiano Ernest; Onanyang, David; Ekou, Justine; Musinguzi, Simon Peter; Ssimbwa, Godfrey; Keneth Iceland, Kasozi
    Background: Stress among medical students is related to their academic lifespan; however, information on brain health among medical students from developing countries continues to be scarce. The objective of this study was to establish perceived academic stress levels, assess the ability to cope with stress, and investigate its effects on the visual reaction time (VRT), audio reaction time (ART), and tactile reaction time (TRT) in the somatosensory cortex among medical students of Uganda. Methods: This was a cross-sectional study conducted among preclinical (n = 88) and clinical (n = 96) undergraduate medical students at Kampala International University Western Campus. A standard Perceived Stress Scale (PSS) was used to categorize stress into low, moderate, and severe while the ability to cope with stress was categorized into below average, average, above average, and superior stresscoper (SS). Data on reaction time were acquired through VRT, ART, and TRT using the catch-a-ruler experiment, and this was analyzed using SPSS version 20. Results: This study shows that preclinical students are more stressed than clinical students (PSS prevalence for low stress = preclinical; clinical: 40, 60%). Moderate stress was 48.4 and 51.6% while high perceived stress was 75 and 25% among preclinical and clinical students. Among male and female students in preclinical years, higher TRT and VRT were found in clinical students showing that stress affects the tactile and visual cortical areas in the brain, although the VRT scores were only significantly (P = 0.0123) poor in male students than female students in biomedical sciences. Also, highly stressed individuals had higher TRT and ART and low VRT. SS had high VRT and ART and low TRT in preclinical students, demonstrating the importance of the visual cortex in stress plasticity. Multiple regression showed a close relationship between PSS, ability to cope with stress, age, and educational level (P < 0.05), demonstrating the importance of social and psychological support, especially in the biomedical sciences. Conclusion: Preclinical students suffer more from stress and are poorer SS than clinical students. This strongly impairs their cortical regions in the brain, thus affecting their academic productivity. Keywords:Brain Stress, Medical Education, Cerebral Cortex, Brains, Africans, Reaction Time (RT), Academic Stress
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    Correction to: Antimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats.
    (Kabale University, 2020) Kalange, Muhamudu; Nansunga, Miriam; Keneth Iceland, Kasozi; Kasolo, Josephine; Namulema, Jackline; Atusiimirwe, Jovial Kasande; Emmanuel Tiyo Ayikobua, Emmanuel Tiyo; Ssempijja, Fred; Munanura, Edson Ireeta; Matama, Kevin; Semuyaba, Ibrahim; Zirintunda, Gerald; Okpanachi, Alfred O.
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    Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19.
    (2021) Al-kuraishy, Hayder M.; Al-Gareeb, Ali Ismail; Mostafa-Hedeab, Gomaa; Keneth Iceland, Kasozi; Zirintunda, Gerald; Aslam, Akhmed; Allahyani, Mamdouh; Welburn, Susan Christina; Batiha, Gaber El-Saber
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a causative virus in the development of coronavirus disease 2019 (Covid-19) pandemic. Respiratory manifestations of SARS-CoV-2 infection such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) leads to hypoxia, oxidative stress, and sympatho-activation and in severe cases leads to sympathetic storm (SS). On the other hand, an exaggerated immune response to the SARS-CoV-2 invasion may lead to uncontrolled release of pro-inflammatory cytokine development of cytokine storm (CS). In Covid-19, there are interactive interactions between CS and SS in the development of multi-organ failure (MOF). Interestingly, cutting the bridge between CS and SS by antiinflammatory and anti-adrenergic agents may mitigate complications that are induced by SARS-CoV-2 infection in severely affected Covid-19 patients. The potential mechanisms of SS in Covid-19 are through different pathways such as hypoxia, which activate the central sympathetic center through carotid bodies chemosensory input and induced proinflammatory cytokines, which cross the blood-brain barrier and activation of the sympathetic center. b2-receptors signaling pathway play a crucial role in the production of pro-inflammatory cytokines, macrophage activation, and B-cells for the production of antibodies with inflammation exacerbation. b-blockers have anti-inflammatory effects through reduction release of pro-inflammatory cytokines with inhibition of NF-kB. In conclusion, b-blockers interrupt this interaction through inhibition of several mediators of CS and SS with prevention development of neural-cytokine loop in SARS-CoV-2 infection. Evidence from this study triggers an idea for future prospective studies to confirm the potential role of b-blockers in the management of Covid-19.
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    Emerging Anthelmintic Resistance in Poultry: Can Ethnopharmacological Approaches Offer a Solution?
    (Kabale University, 2022) Zirintunda, Gerald; Biryomumaisho, Savino; Keneth Iceland, Kasozi; Batiha, Gaber El-Saber; Kateregga, John; Vudriko, Patrick; Nalule, Sarah; Olila, Deogracious; Mariam Kajoba, Mariam; Matama, Kevin; Kwizera, Mercy Rukundo; Ghoneim, Mohammed M.; Abdelhamid, Mahmoud; Alshehri, Sultan; Abdelgawad, Mohamed A.; Acai-Okwee, James; Zaghlool, Sameh S.
    Limited pharmacological studies have been conducted on plant species used against poultry helminths. The objective of this study was to provide a basis for plant based anthelmintics as possible alternatives against poultry anthelmintic resistance. The study justified the need for alternative anthelmintics. The study places emphasis on the increasing anthelmintic resistance, mechanism of resistance, and preparational protocols for plant anthelmintics and their associated mechanism of action. Pharmaceutical studies on plants as alternative therapies for the control of helminthparasites have not been fully explored especially in several developing countries. Plants from a broad range of species produce a wide variety of compounds that are potential anthelmintics candidates. Important phenolic acids have been found in Brassica rapa L. and Terminalia avicenniodes Guill. and Perri that affect the cell signaling pathways and gene expression. Benzo (c) phenanthridine and isoquinoline alkaloids are neurotoxic to helminths. Steroidal saponins (polyphyllin D and dioscin) interact with helminthic mitochondrial activity, alter cell membrane permeability, vacuolation and membrane damage. Benzyl isothiocyanate glucosinolates interfere with DNA replication and protein expression, while isoflavones from Acacia oxyphylla cause helminth flaccid paralysis, inhibit energy generation, and affect calcium utilization. Condensed tannins have been shown to cause the death of nematodes and paralysis leading to expulsion from the gastro-intestinal tract. Flavonoids from Chenopodium album L and Mangifera indica L act through the action of phosphodiesterase and Ca2+-ATPase, and flavonoids and tannins have been shown to act synergistically and are complementary to praziquantel. Artemisinins from Artemisia cina O. Berg are known to disrupt mitochondrial ATP production. Terpenoids from Cucurbita moschata L disrupt neurotransmission leading to paralysis as well as disruption of egg hatching. Yeast particle encapsulated terpenes are effective for the control of albendazole-resistant helminths. Keywords: Synthetic, Toxicity, Safety, Medicine, Ethnoveterinary, Parasites, Nematodes, Plant.
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    Epidemiology of Trypanosomiasis in Wildlife—Implications for Humans at the Wildlife Interface in Africa
    (Kabale University, 2021) Keneth Iceland, Kasozi; Zirintunda, Gerald; Ssempijja, Fred; Buyinza, Bridget; Alzahrani, Khalid J.; Matama, Kevin; Nakimbugwe, Helen N.; Alkazmi, Luay; Onanyang, David; Bogere, Paul; Ochieng, Juma John; Islam, Saher; Matovu, Wycliff; Nalumenya, David Paul; Batiha, Gaber El-Saber; Osuwat, Lawrence Obado; Abdelhamid, Mahmoud; Shen, Tianren; Omadang, Leonard; Welburn, Susan Christina
    While both human and animal trypanosomiasis continue to present as major human and animal public health constraints globally, detailed analyses of trypanosome wildlife reservoir hosts remain sparse. African animal trypanosomiasis (AAT) affects both livestock and wildlife carrying a significant risk of spillover and cross-transmission of species and strains between populations. Increased human activity together with pressure on land resources is increasing wildlife–livestock–human infections. Increasing proximity between human settlements and grazing lands to wildlife reserves and game parks only serves to exacerbate zoonotic risk. Communities living and maintaining livestock on the fringes of wildlife-rich ecosystems require to have in place methods of vector control for prevention of AAT transmission and for the treatment of their livestock. Major Trypanosoma spp. include Trypanosoma brucei rhodesiense Trypanosoma brucei gambiense, and Trypanosoma cruzi, pathogenic for humans, and Trypanosoma vivax, Trypanosoma congolense, Trypanosoma evansi, Trypanosoma brucei brucei, Trypanosoma dionisii, Trypanosoma thomasbancrofti, Trypanosma elephantis, Trypanosoma vegrandis, Trypanosoma copemani, Trypanosoma irwini, Trypanosoma copemani, Trypanosoma gilletti, Trypanosoma theileri, Trypanosoma godfreyi, Trypansoma simiae, and Trypanosoma (Megatrypanum) pestanai. Wildlife hosts for the trypansomatidae include subfamilies of Bovinae, Suidae, Pantherinae, Equidae, Alcephinae, Cercopithecinae, Crocodilinae, Pteropodidae, Peramelidae, Sigmodontidae, and Meliphagidae. Wildlife species are generally considered tolerant to trypanosome infection following centuries of coexistence of vectors and wildlife hosts. Tolerance is influenced by age, sex, species, and physiological condition and parasite challenge. Cyclic transmission through Glossina species occurs for T. congolense, T. simiae, T. vivax, T. brucei, and T. b. rhodesiense, T. b. gambiense, and within Reduviid bugs for T. cruzi. T. evansi is mechanically transmitted, and T. vixax is also commonly transmitted by biting flies including tsetse. Wildlife animal species serve as long-term reservoirs of infection, but the delicate acquired balance between trypanotolerance and trypanosome challenge can be disrupted by an increase in challenge and/or the introduction of new more virulent species into the ecosystem. There is a need to protect wildlife, animal, and human populations from the infectious consequences of encroachment to preserve and protect these populations. In this review, we explore the ecology and epidemiology of Trypanosoma spp. in wildlife. Keywords: Trypanosomes, wildlife, Human-wildlife Interactions, Wildlife-Livestock Interactions, Human African Trypanosomiasis, Sleeping Sickness, Trypanosoma brucei Gambiense, Trypanosoma brucei rhodesiense.
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    Misconceptions on COVID-19 Risk Among Ugandan Men: Results From a Rapid Exploratory Survey, April 2020
    (Kabale University, 2020) Keneth Iceland, Kasozi; MacLeod, Ewan; Ssempijja, Fred; Mahero, Michael W.; Matama, Kevin; Musoke, Grace Henry; Bardosh, Kevin; Ssebuufu, Robinson; Wakoko-Studstil, Florence; Echoru, Isaac; Tiyo Ayikobua, Emmanuel; Mujinya, Regan; Nambuya, Grace; Onohuean, Hope; Zirintunda, Gerald; Ekou, Justine; Welburn, Susan Christina
    Background: Transmission of COVID-19 in developing countries is expected to surpass that in developed countries; however, information on community perceptions of this new disease is scarce. The aim of the study was to identify possible misconceptions among males and females toward COVID-19 in Uganda using a rapid online survey distributed via social media. Methods: A cross-sectional survey carried out in early April 2020 was conducted with 161 Ugandans, who purposively participated in the online questionnaire that assessed understandings of COVID-19 risk and infection. Sixty-four percent of respondents were male and 36% were female. Results: We found significant divergences of opinion on gendered susceptibility to COVID-19. Most female respondents considered infection risk, symptoms, severe signs, and death to be equally distributed between genders. In contrast, male respondents believed they were more at risk of infection, severe symptoms, severe signs, and death (52.7 vs. 30.6%, RR = 1.79, 95% CI: 1.14–2.8). Most women did not share this perception and disagreed that males were at higher risk of infection (by a factor of three), symptoms (79% disagree), severe signs (71%, disagree), and death (70.2% disagree). Overall, most respondents considered children less vulnerable (OR = 1.12, 95% CI: 0.55–2.2) to COVID-19 than adults, that children present with less symptoms (OR = 1.57, 95% CI: 0.77–3.19), and that there would be less mortality in children (OR = 0.92, 95% CI: 0.41–1.88). Of female respondents, 76.4% considered mortality from COVID-19 to be different between the young and the elderly (RR = 1.7, 95% CI: 1.01–2.92) and 92.7% believed young adults would show fewer signs than the elderly, and 71.4% agreed that elderly COVID-19 patients would show more severe signs than the young (OR = 2.2, 95%CI: 1.4, 4.8). While respondents considered that all races were susceptible to the signs and symptoms of infection as well as death from COVID-19, they considered mortality would be highest among white people from Europe and the USA. Some respondents (mostly male 33/102, 32.4%) considered COVID-19 to be a “disease of whites” (30.2%). Conclusion: The WHO has identified women and children in rural communities as vulnerable persons who should be given more attention in the COVID-19 national response programs across Africa; however, our study has found that men in Uganda perceive themselves to be at greater risk and that these contradictory perceptions (including the association of COVID-19 with “the white” race) suggest an important discrepancy in the communication of who is most vulnerable and why. Further research is urgently needed to validate and expand the results of this small exploratory study. Keywords: COVID-19, Uganda, Africa, United Nations Gender , impact children.