Browsing by Author "Ugochukwu Vincent, Igbokwe"

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    Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats
    (FUDMA Journal of Sciences (FJS), 2021) Ugochukwu Vincent, Igbokwe; Ejike, Daniel Eze; Moses Dele, Adams; Karimah Mohammed, Rabiu; Iliya, Ezekiel; Prisca Ojochogu, Ajeka; Peace Ogechukwu, Okpara
    This work focusses on comparative determination of the effects of plant extracts: bitter leaf (BL), sour lime (SL), grape (G), pawpaw (PP) and unripe pineapple (UPA) in female rats induced into malaria with Plasmodiumberghei. Thirty female rats weighing 120-160 g were allotted into five groups (n=6). Group A (negative control) were infected but not treated. Animals in Groups B–E which were infected were given 500 mg/kg body weight (BW) of malanter DS (reference antimalarial drug), 500 mg/kg BW of BL, 250 mg/kg BW each of SL and BL as well as 250 mg/kg BW each of G, PP and UPA. Treatment was done orally once daily for 14 days after which a few related analyses were carried out. Before treatment, parasitemia count of animals in groups B-E was substantially (p<0.05) higher when juxtaposed with group A. AST and ALT activities was substantively (p<0.05) elevated in group B-E when matched with group A. Plasmodium berghei induction notably (p<0.05) lowered white blood cell (WBC) and monocyte (Mono) levels at all groups. After 7 days of treatment, the extracts and drug which appreciably (p<0.05) lowered plasmodium count, RBC, WBC, PCV, Hb, Plat, Lymph, Mono, Granul levels did not meaningfully(p>0.05) affect the activities of ALP, AST and ALT. After 14 days of treatment, the extracts and drug exceptionally (p<0.05) reduced plasmodium count, WBC and ALP activity at all groups. These results give suggestive evidence that the plant extracts either singly or combined, could be a promising anti-plasmodial candidate.
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    Carpolobia lutea methanol root extract reinstates androgenesis and testicular function in cadmiumchallenged rats
    (Academic Journals, 2019) Ejike, Daniel Eze; Precious Nwaka, Okpa; Ugochukwu Vincent, Igbokwe; Moses, Dele Adams; Mohammed Rabiu, Karimah; Emmanuel Tiyo, Ayikobua
    Cadmium produces a wide range of biological dysfunctions in human and laboratory animals where it chiefly affects the testes, whereas, Carpolobia lutea has been known to have antioxidant benefits. This study was intended to investigate the effects of Carpolobia lutea root extracts on testicular hormone function in cadmium-challenged male rats. 48 male Wistar rats (170-190 g) were divided into six groups, each containing eight rats. Experimental animals in control (Group 1) were given 0.2ml/kg body weight (BW) of 10% tween 80; Group two were administered 1mg/kg BW of cadmium (i.p); Group 3 were given 1mg/kg BW of cadmium (i.p) + 100mg/kg BW extract; Group four took 1mg/kg BW of cadmium (i.p) + 200mg/kg BW extract while Group five and six got 100mg/kg and 200mg/kg BW extract respectively. The administration of vehicle and extract was conducted orally for six weeks. Testicular activity of 17 betahydrosteroid dehydrogenase (17β-HSD) and serum testosterone, luteinizing and follicle stimulating hormone (LH, FSH) levels were evaluated. Findings indicated that cadmium statistically (p<0.05) lowered testicular 17β-HSD activity and serum testosterone, LH and FSH levels when compared with those of the control group animals. However, Carpolobia lutea and its co-administration notably (p<0.05) elevated the activity of testicular 17β-HSD and levels of serum testosterone, LH and FSH. The study suggests that Carpolobia lutea extract plays a protective function in ameliorating testicular damage caused by cadmium in rats. This is probably due to the extract’s potential in the management of testicular dysfunction and fecundity in animals.
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    ItemOpen Access
    Carpolobia lutea methanol root extract reinstates androgenesis and testicular function in cadmiumchallenged rats
    (Academic Journals, 2019) Ejike, Daniel Eze; Okpa Precious, Nwaka; Ugochukwu Vincent, Igbokwe; Moses, Dele Adams; Mohammed Rabiu, Karimah; Emmanuel Tiyo, Ayikobua
    Cadmium produces a wide range of biological dysfunctions in human and laboratory animals where it chiefly affects the testes, whereas, Carpolobia lutea has been known to have antioxidant benefits. This study was intended to investigate the effects of Carpolobia lutea root extracts on testicular hormone function in cadmium-challenged male rats. 48 male Wistar rats (170-190 g) were divided into six groups, each containing eight rats. Experimental animals in control (Group 1) were given 0.2ml/kg body weight (BW) of 10% tween 80; Group two were administered 1mg/kg BW of cadmium (i.p); Group 3 were given 1mg/kg BW of cadmium (i.p) + 100mg/kg BW extract; Group four took 1mg/kg BW of cadmium (i.p) + 200mg/kg BW extract while Group five and six got 100mg/kg and 200mg/kg BW extract respectively. The administration of vehicle and extract was conducted orally for six weeks. Testicular activity of 17 betahydrosteroid dehydrogenase (17β-HSD) and serum testosterone, luteinizing and follicle stimulating hormone (LH, FSH) levels were evaluated. Findings indicated that cadmium statistically (p<0.05) lowered testicular 17β-HSD activity and serum testosterone, LH and FSH levels when compared with those of the control group animals. However, Carpolobia lutea and its co-administration notably (p<0.05) elevated the activity of testicular 17β-HSD and levels of serum testosterone, LH and FSH. The study suggests that Carpolobia lutea extract plays a protective function in ameliorating testicular damage caused by cadmium in rats. This is probably due to the extract’s potential in the management of testicular dysfunction and fecundity in animals.
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    Etracarpidium Conophorum Extract Exhibits Anti-Fatigue Activity in Rats Via Reduced Protein Catabolism, Increased Antioxidant Status and Delayed Lactate Elevation
    (FUDMA Journal of Sciences (FJS), 2021) Ugochukwu Vincent, Igbokwe; Ejike, Daniel Eze; Moses Dele, Adams; Karimah Mohammed, Rabiu,; Iliya, Ezekiel; Prisca Ojochogu, Ajeka; Adam Moyosore, Afodun
    Thirty rats of both sexes were assigned into 5 categories of six animals apiece. Animals in the unadministered (control) group were placed on distilled water. Group 1M and Group 1F animals were administered 500 mg/kg body weight (b.w) of T. conophorum aqueous nut extract whereas animals in Group 2M and Group 2F were administered 750 mg/kg dosage of the extricate (0.5 ml) orally once daily for 32 days. Phytoconstituents present in the extract include: saponins, flavonoids, tannins, phenols and alkaloids. The extract at 750mg/kg b.w notably (p<0.05) raised extracellular glucose in masculine rats when matched with males that received 500 mg/kg b.w. The 500 mg/kg dose of the extract appreciably (p<0.05) elevated BUN in both sexes, but with reduction in both groups at 750 mg/kg b.w when juxtaposed with their respective untreated animals. The extract at 500 mg/kg b.w increased LDH activity in male group when compared with male rats that received 750 mg/kg dose. The 750-extract dosage did not statistically (p>0.05) alter LDH activity in both sexes. The extract at 500 and 750mg/kg b.w increased the 3rd‒6th swim in male rats. Substantive (p<0.05) rise in swimming endurance time was first noticed at the 2nd swim when matched up with the control and group treated 500 mg/kg b.w, in female rats. Sequel to these research findings, it is hypothesized that the anti-weakness effect of T. conophorum might be adduced to delayed increase in lactate and reduction in protein catabolism.