Browsing by Author "Iliya, Ezekiel"

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    Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats
    (FUDMA Journal of Sciences (FJS), 2021) Ugochukwu Vincent, Igbokwe; Ejike, Daniel Eze; Moses Dele, Adams; Karimah Mohammed, Rabiu; Iliya, Ezekiel; Prisca Ojochogu, Ajeka; Peace Ogechukwu, Okpara
    This work focusses on comparative determination of the effects of plant extracts: bitter leaf (BL), sour lime (SL), grape (G), pawpaw (PP) and unripe pineapple (UPA) in female rats induced into malaria with Plasmodiumberghei. Thirty female rats weighing 120-160 g were allotted into five groups (n=6). Group A (negative control) were infected but not treated. Animals in Groups B–E which were infected were given 500 mg/kg body weight (BW) of malanter DS (reference antimalarial drug), 500 mg/kg BW of BL, 250 mg/kg BW each of SL and BL as well as 250 mg/kg BW each of G, PP and UPA. Treatment was done orally once daily for 14 days after which a few related analyses were carried out. Before treatment, parasitemia count of animals in groups B-E was substantially (p<0.05) higher when juxtaposed with group A. AST and ALT activities was substantively (p<0.05) elevated in group B-E when matched with group A. Plasmodium berghei induction notably (p<0.05) lowered white blood cell (WBC) and monocyte (Mono) levels at all groups. After 7 days of treatment, the extracts and drug which appreciably (p<0.05) lowered plasmodium count, RBC, WBC, PCV, Hb, Plat, Lymph, Mono, Granul levels did not meaningfully(p>0.05) affect the activities of ALP, AST and ALT. After 14 days of treatment, the extracts and drug exceptionally (p<0.05) reduced plasmodium count, WBC and ALP activity at all groups. These results give suggestive evidence that the plant extracts either singly or combined, could be a promising anti-plasmodial candidate.
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    Etracarpidium Conophorum Extract Exhibits Anti-Fatigue Activity in Rats Via Reduced Protein Catabolism, Increased Antioxidant Status and Delayed Lactate Elevation
    (FUDMA Journal of Sciences (FJS), 2021) Ugochukwu Vincent, Igbokwe; Ejike, Daniel Eze; Moses Dele, Adams; Karimah Mohammed, Rabiu,; Iliya, Ezekiel; Prisca Ojochogu, Ajeka; Adam Moyosore, Afodun
    Thirty rats of both sexes were assigned into 5 categories of six animals apiece. Animals in the unadministered (control) group were placed on distilled water. Group 1M and Group 1F animals were administered 500 mg/kg body weight (b.w) of T. conophorum aqueous nut extract whereas animals in Group 2M and Group 2F were administered 750 mg/kg dosage of the extricate (0.5 ml) orally once daily for 32 days. Phytoconstituents present in the extract include: saponins, flavonoids, tannins, phenols and alkaloids. The extract at 750mg/kg b.w notably (p<0.05) raised extracellular glucose in masculine rats when matched with males that received 500 mg/kg b.w. The 500 mg/kg dose of the extract appreciably (p<0.05) elevated BUN in both sexes, but with reduction in both groups at 750 mg/kg b.w when juxtaposed with their respective untreated animals. The extract at 500 mg/kg b.w increased LDH activity in male group when compared with male rats that received 750 mg/kg dose. The 750-extract dosage did not statistically (p>0.05) alter LDH activity in both sexes. The extract at 500 and 750mg/kg b.w increased the 3rd‒6th swim in male rats. Substantive (p<0.05) rise in swimming endurance time was first noticed at the 2nd swim when matched up with the control and group treated 500 mg/kg b.w, in female rats. Sequel to these research findings, it is hypothesized that the anti-weakness effect of T. conophorum might be adduced to delayed increase in lactate and reduction in protein catabolism.
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    Neuroprotective Effect of Leaf Extract of Moringa Oleifera And Fenofibrate on Learning and Memory in Wistar Rats Subjected to Water Immersion Restraint Stress
    (FUW Trends in Science & Technology Journal, www.ftstjournal.com, 2022) Stephen, Olawale Ajayi; Iliya, Ezekiel; Iliya, Andesire; Agnes, Igimi Odey; Ajayi, Damilola Ife; Ejike, Daniel Eze
    oringa oleifera (Moringaceae) is a medicinal plant used in African traditional medicine against cognitive affections and metabolic diseases. In the present study, the neuroprotective effect of Moringa oleifera leaf extract and Fenofibrate was investigated to evaluate their ameliorative effects on learning and memory in Wistar Rats subjected to water immersion restraint stress (WIS). Twenty five Wistar rats weighing 180 – 200g were randomly selected into five groups (n=5): group A: control (CTL) received distilled water 1ml/kg for one month, group B: moringa oleifera leaf (MOL) extract 2ml/kg for one month, group C: fenofibrate (FF) 2ml/kg for one month, group D: received 2ml/kg of Moringa oleifera leaf extract and Fenofibrate for one month, group E: negative non- treated/control and received normal tap water for one month. Animals in all the groups were starved for 24 hours before the onset of stress procedure, but were allowed access to tap water. After administration for one month, changes in animal cognition were assessed in the Novel Object Recognition Task. The results of both the training and test phases showed that, CTL, MOL+WIS and FF+WIS induced significant increase in object recognition (P < 0.05) compared to MOL+FF+WIS and CTL+WIS groups. These results suggest that MOL+WIS and FF+WIS has memory enhancing effect as observed during the training and test phases of the NORT.
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    Taurine Prevented Biochemical Alterations in Chronic Restraint-Stressed Wistar Rats
    (FUW Trends in Science & Technology Journal, www.ftstjournal.com, 2022) Iliya, Ezekiel; Agnes Igimi, Odey; Stephen Olawale, Ajayi; Ejike, Daniel Eze; Obioha, Mary
    Stress has the potential of altering physiological homeostasis. The body’s ability to cope under stressful stimuli is a vital determinant of health and disease conditions. In this study, Wistar rats were weighed and randomly allocated into four groups (n=6): group A: control (1 ml/kg of distilled water), group B: (100 mg/kg of taurine), group C: (200 mg/kg taurine) and group D: received 400 mg/kg taurine. The treatments were administered once daily (60 minutes) prior to the commencement of the stress sessions by oral gavage for 21 days. During the experiment, concentration of malondialdehyde (MDA) and activity of acetylcholinesterase were evaluated in the fore brain homogenate samples. Other biochemical parameters assayed in the serum were the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). The result revealed significant (p < 0.05) increase in the brain AChE activity in taurine 100 mg/kg when compared to the control group. Also there was significant (p < 0.05) increase in total protein in all the taurine treated groups but a significant (p < 0.05) decrease in albumin in the group that was administered 100 mg/kg taurine when compared with 200 and 400 mg/kg groups. There was no significant (p > 0.05) difference in the serum MDA concentration and activities of SOD, CAT and GPx in all the taurine treated groups when compared with the control group. The results of this study suggested that, taurine has immense potential as an anti-stress agent of great therapeutic relevance