Browsing by Author "Epiu, Isabella"

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    Effect of Vigorous-Intensity Physical Activity on Incident Cognitive Impairment in High-Risk Hypertension.
    (Kabale University, 2024) Kazibwe, Richard; Schaich, Christopher L.; Muhammad, Ahmad Imtiaz; Epiu, Isabella; Namutebi, Juliana H.; Chevli, Parag A.; Kazibwe, Joseph; Hughes, Timothy; Rikhi, Rishi R.; Shapiro, Michael D.; Yeboah, Joseph
    Introduction: We investigated the effect of vigorous physical activity (VPA) on the risk of incident mild cognitive impairment (MCI) and probable dementia among individuals with high-risk hypertension. Methods: Baseline self-reported frequency of VPA was categorized into low VPA (<1 session/week), and high VPA (≥1 session/week). We used multivariate Cox regression analysis to examine the association of VPA categories with incident MCI and probable dementia events. Results: Participants in the high VPA category, compared with low VPA, experienced lower events rates (per 1000 person-years) of MCI (13.9 vs 19.7), probable dementia (6.3 vs 9.0), and MCI/probable dementia (18.5 vs 25.8). In the multivariate Cox regression model, high VPA, compared with low VPA, was associated with lower risk of MCI, probable dementia, and MCI/probable dementia (HR [95% CI]: 0.81 [0.68–0.97], 0.80 [0.63–1.03], and 0.82 [0.70–0.96]), respectively. DISCUSSION: This study provides evidence that VPA may preserve cognitive function in high-risk patients with hypertension.
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    Setting Priorities for African Postoperative Pain Research Through an International Delphi Process
    (International Anesthesia Research Society, 2025) Asfaw, Gebrehiwot; Melkie, Tadesse B.; Shiferaw, Ananya A.; Mwiti, Timothy M.; Nyirigira, Gaston; Retief, Francois; Mikailu, Alfa A.; Zacharia, Amos; Jarju, Ensa; Lakew, Esubalew; Epiu, Isabella; Vishaal, Kissoon; Abed, Lynda; Yimer, Mequanent; Mohamed, Mubarak; Ekor, Oluwayemisi E.; Bukuru, Prudence; Djagbletey, Robert; Ayad, Amany E.; Forget, Patrice; Gebremedhn, Endale G.
    Acute postoperative pain remains a significant challenge in Africa, with prevalence rates of moderate-to-severe pain reaching 91.4–95%, exacerbated by resource constraints, inadequate training, and policy gaps in low- and middle-income countries. This perspective article employs a modified two-round Delphi process involving 174 multidisciplinary experts from 25 African countries to identify the top 10 research priorities and three key strategies for addressing postoperative pain. Priorities, ranked by consensus magnitude, include evaluating current practices, developing cost-effective multimodal analgesia, enhancing regional anesthesia training, assessing patient satisfaction, identifying barriers/enablers, examining impacts on surgical outcomes, exploring preemptive analgesia roles, addressing pediatric barriers, and predicting acute/chronic pain risks. Strategies emphasize developing regional anesthesia guidelines, harmonized multidisciplinary curricula, and context-specific pain assessment tools. These priorities aim to inform evidence-based policies, optimize resource allocation, and improve patient-centered care across diverse African settings.