Browsing by Author "Chevli, Parag A."

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    Effect of Vigorous-Intensity Physical Activity on Incident Cognitive Impairment in High-Risk Hypertension.
    (Kabale University, 2024) Kazibwe, Richard; Schaich, Christopher L.; Muhammad, Ahmad Imtiaz; Epiu, Isabella; Namutebi, Juliana H.; Chevli, Parag A.; Kazibwe, Joseph; Hughes, Timothy; Rikhi, Rishi R.; Shapiro, Michael D.; Yeboah, Joseph
    Introduction: We investigated the effect of vigorous physical activity (VPA) on the risk of incident mild cognitive impairment (MCI) and probable dementia among individuals with high-risk hypertension. Methods: Baseline self-reported frequency of VPA was categorized into low VPA (<1 session/week), and high VPA (≥1 session/week). We used multivariate Cox regression analysis to examine the association of VPA categories with incident MCI and probable dementia events. Results: Participants in the high VPA category, compared with low VPA, experienced lower events rates (per 1000 person-years) of MCI (13.9 vs 19.7), probable dementia (6.3 vs 9.0), and MCI/probable dementia (18.5 vs 25.8). In the multivariate Cox regression model, high VPA, compared with low VPA, was associated with lower risk of MCI, probable dementia, and MCI/probable dementia (HR [95% CI]: 0.81 [0.68–0.97], 0.80 [0.63–1.03], and 0.82 [0.70–0.96]), respectively. DISCUSSION: This study provides evidence that VPA may preserve cognitive function in high-risk patients with hypertension.