Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups
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Date
2023-03-04
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Journal ISSN
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Publisher
Elsevier
Abstract
Over time, the use of plant-derived agents in the management of various human health conditions has gained a
lot of attention. The study assessed the hepatoprotective potential of ethyl acetate fraction Tamarindus indica
leaves (EFTI) during prenatal aluminum chloride exposure. Pregnant rats were divided into 5 groups (n = 4);
Group I rats were administered 2 ml kg− 1 of distilled water (negative control), Group II rats received only 200
mg kg− 1 aluminum chloride (positive control), Group III rats were administered 200 mg kg− 1 aluminum chloride
and 400 mg kg− 1 EFTI, Group IV rats were administered 200 mg kg− 1 aluminum chloride and 800 mg kg− 1 EFTI,
Group V rats were administered 200 mg kg− 1 aluminum chloride and 300 mg kg− 1 Vit E (comparative control).
On postnatal day 1, the pups were euthanized, and liver tissues were harvested for the biochemical study (tissue
levels of malondialdehyde, caspase-3, tumor necrosis factor-alpha, aspartate aminotransferase, alkaline phos - phatase, and alanine aminotransferases) and the liver histological examination. The administration of EFTI was
marked with significant improvement in the tissue levels of malondialdehyde, caspase-3, tumor necrosis factor-alpha, aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferases. There was a marked
improvement in histopathological changes associated with prenatal aluminum chloride exposure. In conclusion,
the administration of EFTI was protective during prenatal aluminum chloride exposure of the liver in Wistar rats,
and is mediated by the anti-lipid peroxidative, antiapoptotic, and anti-inflammatory activity of EFTI.
Description
Keywords
Caspase-3 Tumor necrosis factor-alpha Medicinal plant Reticular fiber Aluminum toxicity