Buyinza, DanielYang, Li JunDerese, SolomonNdakala, AlbertCoghi, PaoloHeydenreich, MatthiasWong, Vincent Kam WaiMöller, Heiko M.Yenesew, Abiy2025-09-022025-09-022019Daniel Buyinza, Li Jun Yang, Solomon Derese, Albert Ndakala, Paolo Coghi, Matthias Heydenreich, Vincent Kam Wai Wong, Heiko M. Möller & Abiy Yenesew (2019): Cytotoxicity of isoflavones from Millettia dura, Natural Product Research, DOI: 10.1080/14786419.2019.16603351478-6427http://hdl.handle.net/20.500.12493/2940The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 lM. Durmillone was the most active with IC50 values of 6.6 lM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 ¼ 58.4 lM), LO2 hepatocytes (IC50 78.7 lM) and CCD19Lu fibroblasts (IC50 >100 lM).enAttribution-NonCommercial-NoDerivs 3.0 United Stateshttp://creativecommons.org/licenses/by-nc-nd/3.0/us/Millettia duraLeguminosaeisoflavonecytotoxicityArticle