A Revised Protecting Group Strategy Enables a Divergent Synthesis of Prenylated Isoflavones from Psoralea corylifolia

Gliszczinskia Sarah von ChamierSperlicha EricKellinga AlexandraKwesiga GeorgeSchmidt Bernd2025-06-132025-06-132025von Chamier Gliszczinski, S., Sperlich, E., Kelling, A., Kwesiga, G., & Schmidt, B. (2025). A Revised Protecting Group Strategy Enables a Divergent Synthesis of Prenylated Isoflavones from Psoralea corylifolia. Synthesis, 57(11), 1833-1847.10.1055/a-2501-4796;http://hdl.handle.net/20.500.12493/2918Three bioactive prenylated isoflavone natural products were synthesized for the first time, using a combination of Pd-catalyzed Suzuki–Miyaura coupling for installing the B-ring, microwave-promoted Claisen rearrangement of allyl ethers, and Ru-catalyzed olefin cross me tathesis for obtaining the prenyl substituents. Careful consideration of the protecting group strategy turned out to be vital for the success of these total syntheses.enAttribution-NonCommercial-NoDerivs 3.0 United Stateshttp://creativecommons.org/licenses/by-nc-nd/3.0/us/isoflavonesSuzuki couplingClaisen rearrangementole fin metathesisprotecting groupsA Revised Protecting Group Strategy Enables a Divergent Synthesis of Prenylated Isoflavones from Psoralea corylifoliaArticle