Cytotoxicity of isoflavones from Millettia dura
| dc.contributor.author | Buyinza, Daniel | |
| dc.contributor.author | Yang, Li Jun | |
| dc.contributor.author | Derese, Solomon | |
| dc.contributor.author | Ndakala, Albert | |
| dc.contributor.author | Coghi, Paolo | |
| dc.contributor.author | Heydenreich, Matthias | |
| dc.contributor.author | Wong, Vincent Kam Wai | |
| dc.contributor.author | Möller, Heiko M. | |
| dc.contributor.author | Yenesew, Abiy | |
| dc.date.accessioned | 2025-09-02T17:50:55Z | |
| dc.date.available | 2025-09-02T17:50:55Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 lM. Durmillone was the most active with IC50 values of 6.6 lM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 ¼ 58.4 lM), LO2 hepatocytes (IC50 78.7 lM) and CCD19Lu fibroblasts (IC50 >100 lM). | |
| dc.description.sponsorship | International Science Program (ISP, KEN 02) | |
| dc.identifier.citation | Daniel Buyinza, Li Jun Yang, Solomon Derese, Albert Ndakala, Paolo Coghi, Matthias Heydenreich, Vincent Kam Wai Wong, Heiko M. Möller & Abiy Yenesew (2019): Cytotoxicity of isoflavones from Millettia dura, Natural Product Research, DOI: 10.1080/14786419.2019.1660335 | |
| dc.identifier.issn | 1478-6427 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.12493/2940 | |
| dc.language.iso | en | |
| dc.publisher | Taylor & Francis | |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | |
| dc.subject | Millettia dura | |
| dc.subject | Leguminosae | |
| dc.subject | isoflavone | |
| dc.subject | cytotoxicity | |
| dc.title | Cytotoxicity of isoflavones from Millettia dura | |
| dc.type | Article |