Emerging Anthelmintic Resistance in Poultry: Can Ethnopharmacological Approaches Offer a Solution?

Simple item page
dc.contributor.authorZirintunda, Gerald
dc.contributor.authorBiryomumaisho, Savino
dc.contributor.authorKeneth Iceland, Kasozi
dc.contributor.authorBatiha, Gaber El-Saber
dc.contributor.authorKateregga, John
dc.contributor.authorVudriko, Patrick
dc.contributor.authorNalule, Sarah
dc.contributor.authorOlila, Deogracious
dc.contributor.authorMariam Kajoba, Mariam
dc.contributor.authorMatama, Kevin
dc.contributor.authorKwizera, Mercy Rukundo
dc.contributor.authorGhoneim, Mohammed M.
dc.contributor.authorAbdelhamid, Mahmoud
dc.contributor.authorAlshehri, Sultan
dc.contributor.authorAbdelgawad, Mohamed A.
dc.contributor.authorAcai-Okwee, James
dc.contributor.authorZaghlool, Sameh S.
dc.date.accessioned2023-02-03T05:37:01Z
dc.date.available2023-02-03T05:37:01Z
dc.date.issued2022
dc.description.abstractLimited pharmacological studies have been conducted on plant species used against poultry helminths. The objective of this study was to provide a basis for plant based anthelmintics as possible alternatives against poultry anthelmintic resistance. The study justified the need for alternative anthelmintics. The study places emphasis on the increasing anthelmintic resistance, mechanism of resistance, and preparational protocols for plant anthelmintics and their associated mechanism of action. Pharmaceutical studies on plants as alternative therapies for the control of helminthparasites have not been fully explored especially in several developing countries. Plants from a broad range of species produce a wide variety of compounds that are potential anthelmintics candidates. Important phenolic acids have been found in Brassica rapa L. and Terminalia avicenniodes Guill. and Perri that affect the cell signaling pathways and gene expression. Benzo (c) phenanthridine and isoquinoline alkaloids are neurotoxic to helminths. Steroidal saponins (polyphyllin D and dioscin) interact with helminthic mitochondrial activity, alter cell membrane permeability, vacuolation and membrane damage. Benzyl isothiocyanate glucosinolates interfere with DNA replication and protein expression, while isoflavones from Acacia oxyphylla cause helminth flaccid paralysis, inhibit energy generation, and affect calcium utilization. Condensed tannins have been shown to cause the death of nematodes and paralysis leading to expulsion from the gastro-intestinal tract. Flavonoids from Chenopodium album L and Mangifera indica L act through the action of phosphodiesterase and Ca2+-ATPase, and flavonoids and tannins have been shown to act synergistically and are complementary to praziquantel. Artemisinins from Artemisia cina O. Berg are known to disrupt mitochondrial ATP production. Terpenoids from Cucurbita moschata L disrupt neurotransmission leading to paralysis as well as disruption of egg hatching. Yeast particle encapsulated terpenes are effective for the control of albendazole-resistant helminths. Keywords: Synthetic, Toxicity, Safety, Medicine, Ethnoveterinary, Parasites, Nematodes, Plant.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12493/940
dc.language.isoen_USen_US
dc.publisherKabale Universityen_US
dc.subjectSyntheticen_US
dc.subjectToxicityen_US
dc.subjectSafetyen_US
dc.subjectMedicineen_US
dc.subjectEthnoveterinaryen_US
dc.subjectParasitesen_US
dc.subjectNematodesen_US
dc.subjectPlant.en_US
dc.titleEmerging Anthelmintic Resistance in Poultry: Can Ethnopharmacological Approaches Offer a Solution?en_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
fphar-12-774896.pdf
Size:
2.6 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

School of Medicine (KABSOM)