A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda

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dc.contributor.authorKeneth Iceland, Kasozi
dc.contributor.authorAnne, Laudisoit
dc.contributor.authorLawrence Obado, Osuwat
dc.contributor.authorGaber El-Saber, Batiha
dc.contributor.authorNaif E. Al, Omairi
dc.contributor.authorEric, Aigbogun
dc.contributor.authorHerbert Izo, Ninsiima
dc.contributor.authorIbe Michael, Usman
dc.contributor.authorLisa M., DeTora
dc.contributor.authorEwan Thomas, MacLeod
dc.contributor.authorHalima, Nalugo
dc.contributor.authorFrancis P., Crawley
dc.contributor.authorBarbara E., Bierer
dc.contributor.authorDaniel Chans, Mwandah
dc.contributor.authorCharles Drago, Kato
dc.contributor.authorKenedy, Kiyimba
dc.contributor.authorEmmanuel Tiyo, Ayikobua
dc.contributor.authorLinda, Lillian
dc.contributor.authorKevin, Matama
dc.contributor.authorShui Ching, Nelly Mak
dc.contributor.authorDavid, Onanyang
dc.contributor.authorTheophilus, Pius
dc.contributor.authorLinda, Lillian
dc.contributor.authorKevin, Matama
dc.contributor.authorShui Ching, Nelly Mak
dc.contributor.authorDavid, Onanyang
dc.contributor.authorTheophilus, Pius
dc.contributor.authorDavid Paul, Nalumenya
dc.contributor.authorRobinson, Ssebuufu
dc.contributor.authorNina Olivia, Rugambwa
dc.contributor.authorGrace Henry, Musoke
dc.contributor.authorKevin, Bardosh
dc.contributor.authorJuma John, Ochieng
dc.contributor.authorFred, Ssempijja
dc.contributor.authorPatrick, Kyamanywa
dc.contributor.authorGabriel, Tumwine
dc.contributor.authorKhalid J., Alzahrani
dc.contributor.authorSusan Christina, Welburn
dc.date.accessioned2023-02-02T05:56:53Z
dc.date.available2023-02-02T05:56:53Z
dc.date.issued2021-03-12
dc.description.abstractBackground—misinformation and mistrust often undermines community vaccine uptake, yet information in rural communities, especially of developing countries, is scarce. This study aimed to identify major challenges associated with coronavirus disease 2019 (COVID-19) vaccine clinical trials among healthcare workers and staff in Uganda. Methods—a rapid exploratory survey was conducted over 5 weeks among 260 respondents (66% male) from healthcare centers across the country using an online questionnaire. Twenty-seven questions assessed knowledge, confidence, and trust scores on COVID-19 vaccine clinical trials from participants in 46 districts in Uganda. Results—we found low levels of knowledge (i.e., confusing COVID-19 with Ebola) with males being more informed than females (OR = 1.5, 95% CI: 0.7–3.0), and mistrust associated with policy decisions to promote herbal treatments in Uganda and the rushed international clinical trials, highlighting challenges for the upcoming Oxford–AstraZeneca vaccinations. Knowledge, confidence and trust scores were higher among the least educated (certificate vs. bachelor degree holders). We also found a high level of skepticism and possible community resistance to DNA recombinant vaccines, such as the Oxford–AstraZeneca vaccine. Preference for herbal treatments (38/260; 14.6%, 95% CI: 10.7–19.3) currently being promoted by the Ugandan government raises major policy concerns. High fear and mistrust for COVID-19 vaccine clinical trials was more common among wealthier participants and more affluent regions of the country. Conclusion—our study found that knowledge, confidence, and trust in COVID-19 vaccines was low among healthcare workers in Uganda, especially those with higher wealth and educational status. There is a need to increase transparency and inclusive participation to address these issues before new trials of COVID-19 vaccines are initiateden_US
dc.description.sponsorshipKabale Universityen_US
dc.identifier.citationKasozi, K.I.; Laudisoit, A.; Osuwat, L.O.; Batiha, G.E.-S.; Al Omairi, N.E.; Aigbogun, E.; Ninsiima, H.I.; Usman, I.M.; DeTora, L.M.; MacLeod, E.T.; et al. A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda. Vaccines 2021, 9, 253. https://doi.org/10.3390/ vaccines9030253en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12493/929
dc.language.isoenen_US
dc.publisherMDPI.en_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectCOVID-19 clinical trials in resource poor countriesen_US
dc.subjectCOVID-19en_US
dc.subjectClinical trials in Africaen_US
dc.subjectCOVID-19 and medical workers;en_US
dc.subjectVaccinesen_US
dc.subjectCOVAXen_US
dc.titleA Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Ugandaen_US
dc.typeArticleen_US

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