Antimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats.

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dc.contributor.authorKalange, Muhamudu
dc.contributor.authorNansunga, Miriam
dc.contributor.authorKeneth Iceland, Kasozi
dc.contributor.authorKasolo, Josephine
dc.contributor.authorNamulema, Jackline
dc.contributor.authorKasande Atusiimirwe, Jovile
dc.contributor.authorTiyo Ayikobua, Emanuel
dc.contributor.authorSsempijja, Fred
dc.contributor.authorMunanura, Edson Ireeta
dc.contributor.authorMatama, Kevin
dc.contributor.authorSemuyaba, Ibrahim
dc.contributor.authorZirintunda, Gerald Gerald
dc.contributor.authorOkpanachi, Alfred Omachonu
dc.date.accessioned2023-01-31T11:50:06Z
dc.date.available2023-01-31T11:50:06Z
dc.date.issued2020
dc.description.abstractObjective: Antimalarials are globally used against plasmodium infections, however, information on the safety of new antimalarial combination therapies on the gastric mucosa is scarce. The aim of this study was to investigate the effects of Artesunate-Amodiaquine and Artemether-Lumefantrine on ulcer induction. Malondialdehyde (MDA), reduced glutathione (GSH) and major histological changes in male Wistar rats following ulcer induction using Indomethacin were investigated. Gastric ulcers were in four groups; Group I was administered Artesunate, group II received Artesunate- Amodiaquine, group III received Artemether-Lumefantrine, and group IV was a positive control (normal saline). GroupV was the negative control consisting of healthy rats. Results: Antimalarial combination therapies were associated with a high gastric ulcer index than a single antimalarial agent, Artesunate. In addition, levels of MDA were significantly higher in the combination of therapies while levels of GSH were lower in comparison to Artesunate and the negative control. Microscopically, antimalarial combination therapies were associated with severe inflammation and tissue damage than Artesunate in the gastric mucosa showing that antimalarial combination therapies exert their toxic effects through oxidative stress mechanisms, and this leads to cellular damage. Findings in this study demonstrate a need to revisit information on the pharmacodynamics of major circulating antimalarial agents in developing countries. Keywords: Antimalarials, Pharmacodynamics, Antimalarial Agents, Malaria, Developing Countries, Gastric Ulcers.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12493/905
dc.publisherKabale Universityen_US
dc.subjectAntimalarialsen_US
dc.subjectPharmacodynamicsen_US
dc.subjectAntimalarial Agentsen_US
dc.subjectMalariaen_US
dc.subjectDeveloping Countriesen_US
dc.subjectGastric Ulceren_US
dc.titleAntimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats.en_US
dc.typeArticleen_US

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