Neuroprotective Effect of Leaf Extract of Moringa Oleifera And Fenofibrate on Learning and Memory in Wistar Rats Subjected to Water Immersion Restraint Stress
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Date
2022
Journal Title
Journal ISSN
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Publisher
FUW Trends in Science & Technology Journal, www.ftstjournal.com
Abstract
oringa oleifera (Moringaceae) is a medicinal plant used in African traditional medicine against cognitive
affections and metabolic diseases. In the present study, the neuroprotective effect of Moringa oleifera leaf extract
and Fenofibrate was investigated to evaluate their ameliorative effects on learning and memory in Wistar Rats
subjected to water immersion restraint stress (WIS). Twenty five Wistar rats weighing 180 – 200g were randomly
selected into five groups (n=5): group A: control (CTL) received distilled water 1ml/kg for one month, group B:
moringa oleifera leaf (MOL) extract 2ml/kg for one month, group C: fenofibrate (FF) 2ml/kg for one month, group
D: received 2ml/kg of Moringa oleifera leaf extract and Fenofibrate for one month, group E: negative non-
treated/control and received normal tap water for one month. Animals in all the groups were starved for 24 hours
before the onset of stress procedure, but were allowed access to tap water. After administration for one month,
changes in animal cognition were assessed in the Novel Object Recognition Task. The results of both the training
and test phases showed that, CTL, MOL+WIS and FF+WIS induced significant increase in object recognition (P <
0.05) compared to MOL+FF+WIS and CTL+WIS groups. These results suggest that MOL+WIS and FF+WIS has
memory enhancing effect as observed during the training and test phases of the NORT.
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Keywords
Neuroprotective, learning and memory, Moringa Oleifera,, Fenofibrate, Stress